反应详情

Activated manganese dioxide (400 mg) is added to a solution of 9-methoxy-2,3,4,6,7,12-hexahydroindolo[2,3-a]quinolizin-4-one (150 mg) in THF (5 ml). After refluxing for 2 h 30, the mixture is cooled and activated manganese dioxide (400 mg) is again added. The medium is refluxed for 2 h 30. After filtration and washing of the dioxide with an ethyl acetate/methanol mixture (98/2) and after separation on a preparative plate, 9-methoxy4,6,7,12-tetrahydroindolo[2,3-a]quinolizin-4-one is obtained (55% yield).

1. temperatureAfter refluxing for 2 h 30
2. temperaturethe mixture is cooled
3. temperatureThe medium is refluxed for 2 h 30
4. filtrationAfter filtration
5. washwashing of the dioxide with an ethyl acetate/methanol mixture (98/2)
6. customafter separation on a preparative plate