反应详情

Activated manganese dioxide (400 mg) is added to a solution of 9-methoxy-2,3,4,6,7,12-hexahydroindolo[2,3-a]quinolizin-4-one (150 mg) in THF (5 ml). After refluxing for 2 h 30, the mixture is cooled and activated manganese dioxide (400 mg) is again added. The medium is refluxed for 24 h. After filtration ard washing of the dioxide with an ethyl acetate/methanol mixture (98/2), and after recrystallization from ethyl acetate, 9-methoxy4,12-dihydroindolo[2,3-a]quinolizin-4-one is obtained.

1. temperatureAfter refluxing for 2 h 30
2. temperaturethe mixture is cooled
3. temperatureThe medium is refluxed for 24 h
4. filtrationAfter filtration
5. washard washing of the dioxide with an ethyl acetate/methanol mixture (98/2)
6. customafter recrystallization from ethyl acetate