反应详情

A solution of (R)-(3-chloro-phenyl)-hydroxy-acetic acid (19.98 g) in methanol (250 ml) containing concentrated sulphuric acid (1 ml) was heated under reflux for 6.5 h. The solution was cooled, neutralised with aqueous sodium bicarbonate solution, and concentrated. The residue was dissolved in ethyl acetate, washed with aqueous sodium bicarbonate solution, dried, and evaporated to give the title compound (21.13 g) as a pale-yellow oil.

1. temperaturewas heated
2. temperatureunder reflux for 6.5 h
3. temperatureThe solution was cooled
4. concentrationconcentrated
5. dissolutionThe residue was dissolved in ethyl acetate
6. washwashed with aqueous sodium bicarbonate solution
7. customdried
8. customevaporated