Methanol → HCID 54558571, compound

HRID 1004076Notes

Reaction equation

HRID 1004076 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[C:4]([C:12]([F:15])([F:14])[F:13])[CH:3]=1.S(=O)(=O)(O)O.[CH3:21]O>>[CH3:21][O:10][C:9](=[O:11])[CH2:8][C:5]1[CH:6]=[CH:7][C:2]([NH2:1])=[CH:3][C:4]=1[C:12]([F:13])([F:14])[F:15]

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 18794322HCID 18794322, compound

Product 1

HCID 54558571HCID 54558571, compound

Procedure

A solution of (4-amino-2-trifluoromethyl-phenyl)-acetic acid (0.082 g) in methanol (10 ml) containing concentrated sulphuric acid (0.1 ml) was heated under reflux for 2 h. The solution was cooled, concentrated, and partitioned between ethyl acetate and aqueous sodium carbonate solution. The organic phase was separated, dried, and concentrated to give the title compound as a yellow solid (0.089 g)

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 2 h
  3. temperatureThe solution was cooled
  4. concentrationconcentrated
  5. custompartitioned between ethyl acetate and aqueous sodium carbonate solution
  6. customThe organic phase was separated
  7. customdried
  8. concentrationconcentrated

Sources & evidence

ORD record
ord-fe182dee02de4beaa273495782157bb8
Source dataset
uspto-grants-2000_04
Patent number
US06048872

Reaction notes

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