Water → 3-Chloro-5,6-dimethoxy-1-benzothiophene-2-carboxylic acid

HRID 1004113Notes

Reaction equation

HRID 1004113 reaction equation
[OH2:1].[Cl:2][C:3]1[C:4]2[CH:14]=[C:13]([O:15][CH3:16])[C:12]([O:17][CH3:18])=[CH:11][C:5]=2[S:6][C:7]=1[C:8](Cl)=[O:9]>O1CCOCC1>[Cl:2][C:3]1[C:4]2[CH:14]=[C:13]([O:15][CH3:16])[C:12]([O:17][CH3:18])=[CH:11][C:5]=2[S:6][C:7]=1[C:8]([OH:1])=[O:9]

Participants

4

Reactant 2

HCID 962WaterHCID 110336193-Chloro-5,6-dimethoxy-benzo[b]thiophene-2-carbonyl chloride

Product 1

HCID 28528713-Chloro-5,6-dimethoxy-1-benzothiophene-2-carboxylic acid

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

40 ml of water are added to a solution of 70 mmol of the compound of Step A in 250 ml of dioxane. After 20 hours' reflux and then return to room temperature, a precipitate forms. After filtration and rinsing with water until neutral, the precipitate is dried over P2O5 under reduced pressure. 18.6 g of the expected product are thus isolated.

Workup

  1. temperatureAfter 20 hours' reflux
  2. customreturn to room temperature
  3. filtrationAfter filtration
  4. washrinsing with water until neutral, the precipitate
  5. dry with materialis dried over P2O5 under reduced pressure

Sources & evidence

ORD record
ord-d7390a7b003241618f8842b890c59005
Source dataset
uspto-grants-2000_04
Patent number
US06048875

Reaction notes

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