HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-Chloro-5,6-dimethoxy-1-benzothiophene-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 3-Chloro-5,6-dimethoxy-benzo[b]thiophene-2-carbonyl chloride | HCID 11033619 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Chloro-5,6-dimethoxy-1-benzothiophene-2-carboxylic acid | HCID 2852871 | — |
Reaction Steps
40 ml of water are added to a solution of 70 mmol of the compound of Step A in 250 ml of dioxane. After 20 hours' reflux and then return to room temperature, a precipitate forms. After filtration and rinsing with water until neutral, the precipitate is dried over P2O5 under reduced pressure. 18.6 g of the expected product are thus isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06048875 |
| Source dataset | uspto-grants-2000_04 |
| ORD ID | ord-d7390a7b003241618f8842b890c59005 |
| Source note | uspto-grants-2000_04 |