Water → Sodium (E)-3-[5,6-dimethoxy-3-(4-methoxyphenoxy)benzo[b]thiophen-2-yl]-2-(4-pyridinyl)-2-propenoate

HRID 1004119Notes

Reaction equation

O.[CH3:2][O:3][C:4]1[C:32]([O:33][CH3:34])=[CH:31][C:7]2[S:8][C:9](/[CH:20]=[C:21](\[C:25]3[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=3)/[C:22]([OH:24])=[O:23])=[C:10]([O:11][C:12]3[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=3)[C:6]=2[CH:5]=1.[OH-].[Na+:36]>>[CH3:2][O:3][C:4]1[C:32]([O:33][CH3:34])=[CH:31][C:7]2[S:8][C:9](/[CH:20]=[C:21](\[C:25]3[CH:26]=[CH:27][N:28]=[CH:29][CH:30]=3)/[C:22]([O-:24])=[O:23])=[C:10]([O:11][C:12]3[CH:13]=[CH:14][C:15]([O:18][CH3:19])=[CH:16][CH:17]=3)[C:6]=2[CH:5]=1.[Na+:36]

Participants

Reactant 3

HCID 962Water

HCID 14798Sodium Hydroxide

HCID 9912231(E)-3-[5,6Dimethoxy-3-(4-methoxyphenoxy)benzo[b]thiophen-2-yl]-2-(4-pyridinyl)-2-propenoic acid

Product 1

HCID 86755304Sodium (E)-3-[5,6-dimethoxy-3-(4-methoxyphenoxy)benzo[b]thiophen-2-yl]-2-(4-pyridinyl)-2-propenoate

Procedure

Water is added to a suspension of 1.16 g of the product of Example 2 in 2.5 ml of 1N sodium hydroxide solution until completely diluted. Lyophilisation enables 1.22 g of the expected product to be isolated.

Workup

additionuntil completely diluted

Sources & evidence

ORD record: ord-e91376d6017c4452969dc79bba313799
Source dataset: uspto-grants-2000_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06048875

Reaction notes

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