HCID 86755305, compound → HCID 18794426, compound

HRID 1004121Notes

Reaction equation

HRID 1004121 reaction equation
[CH3:1][O:2][C:3]1[C:31]([O:32][CH3:33])=[CH:30][C:6]2[S:7][C:8](/[CH:19]=[C:20](\[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)/[C:21]([O-:23])=[O:22])=[C:9]([O:10][C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)[C:5]=2[CH:4]=1.[Na+].[H][H]>CO.[Pd]>[CH3:1][O:2][C:3]1[C:31]([O:32][CH3:33])=[CH:30][C:6]2[S:7][C:8]([CH2:19][CH:20]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[C:21]([OH:23])=[O:22])=[C:9]([O:10][C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)[C:5]=2[CH:4]=1

Participants

5

Reactant 2

HCID 86755305HCID 86755305, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18794426HCID 18794426, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The compound obtained in Example 6 after Step F is used as substrate, which is treated with a stream of hydrogen in the presence of 10% Pd/C in methanol for 24 hours. Filtration, at the end of the reaction, followed by chromatography over silica gel enables the expected product to be isolated.

Workup

  1. filtrationFiltration
  2. customat the end of the reaction

Sources & evidence

ORD record
ord-aae66f96e262421eb610ab7439dfc200
Source dataset
uspto-grants-2000_04
Patent number
US06048875

Reaction notes

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