Bis(2-chloroethyl)amine hydrochloride → 1-[4-[(4-Fluorophenyl)methyl]phenyl]piperazine

Participants

Reaction Conditions

Reaction Steps

A mixture of 500 mg of 4-(4-fluorophenyl)methylaniline and 445 mg of bis(2-chloroethyl)amine hydrochloride was stirred at 100° C. for two hours, then gradually raised in temperature and stirred at 200° C. for a further two hours. This was cooled to room temperature, then the product was purified by silica gel column chromatography (chloroform:methanol:water (2% acetic acid)=65:35:5) to obtain the above-referenced compound (10) in an amount of 503 mg (yield 75%).

Provenance & Evidence