反应详情

温度

100 °C

A mixture of 500 mg of 4-(4-fluorophenyl)methylaniline and 445 mg of bis(2-chloroethyl)amine hydrochloride was stirred at 100° C. for two hours, then gradually raised in temperature and stirred at 200° C. for a further two hours. This was cooled to room temperature, then the product was purified by silica gel column chromatography (chloroform:methanol:water (2% acetic acid)=65:35:5) to obtain the above-referenced compound (10) in an amount of 503 mg (yield 75%).

1. temperaturegradually raised in temperature
2. stirringstirred at 200° C. for a further two hours
3. temperatureThis was cooled to room temperature
4. customthe product was purified by silica gel column chromatography (chloroform:methanol:water (2% acetic acid)=65:35:5)