2-(4-Fluorophenyl)oxybutyl bromide → 1-[4-(4-Fluorophenyl)oxybutyl]-4-(4-phenoxyphenyl)piperidine

HRID 1004133Notes

Reaction equation

HRID 1004133 reaction equation
OC1C=CC(/[CH:8]=[CH:9]/[CH2:10][N:11]2[CH2:16][CH2:15][CH:14]([C:17]3[CH:22]=[CH:21][C:20]([O:23]C4C=CC=CC=4)=[CH:19][CH:18]=3)[CH2:13][CH2:12]2)=CC=1OC.[F:32][C:33]1[CH:38]=[CH:37][C:36]([O:39][CH:40](CC)CBr)=[CH:35][CH:34]=1>>[F:32][C:33]1[CH:34]=[CH:35][C:36]([O:39][CH2:40][CH2:8][CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][CH:14]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)=[CH:19][CH:18]=3)[CH2:13][CH2:12]2)=[CH:37][CH:38]=1

Participants

3

Reactant 2

HCID 184121342-(4-Fluorophenyl)oxybutyl bromideHCID 18412177(E)-1-[3-(4-hydroxy-3-methoxyphenyl)-2-propenyl]-4-(4-phenoxyphenyl)piperidine

Product 1

HCID 184121371-[4-(4-Fluorophenyl)oxybutyl]-4-(4-phenoxyphenyl)piperidine

Procedure

The same procedure was followed as in Example 11 using the compound (9) synthesized in Example 2 and 2-(4-fluorophenyl)oxybutyl bromide to produce the above.

Workup

  1. customto produce the above

Sources & evidence

ORD record
ord-6ab07af4c99649eab029ed2bedeeff0a
Source dataset
uspto-grants-2000_04
Patent number
US06048876

Reaction notes

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