Iodoethane → 1-Ethyl-4-(4-phenoxyphenyl)piperidine

HRID 1004138Notes

Reaction equation

HRID 1004138 reaction equation
OC1C=CC(/C=[CH:9]/[CH2:10][N:11]2[CH2:16][CH2:15][CH:14]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[CH:19][CH:18]=3)[CH2:13][CH2:12]2)=CC=1OC.C(I)C>>[CH2:10]([N:11]1[CH2:16][CH2:15][CH:14]([C:17]2[CH:22]=[CH:21][C:20]([O:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)=[CH:19][CH:18]=2)[CH2:13][CH2:12]1)[CH3:9]

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 18412177(E)-1-[3-(4-hydroxy-3-methoxyphenyl)-2-propenyl]-4-(4-phenoxyphenyl)piperidine

Product 1

HCID 187944781-Ethyl-4-(4-phenoxyphenyl)piperidine

Procedure

The same procedure was followed as in Example 11 using the compound (9) synthesized in Example 2 and ethyl iodide to produce the above.

Workup

  1. customto produce the above

Sources & evidence

ORD record
ord-7d86160b00bb437fa6242d4470210748
Source dataset
uspto-grants-2000_04
Patent number
US06048876

Reaction notes

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