2-Bromopropiophenone → 1-(1-Benzoylethyl)-4-(4-phenoxyphenyl)piperidine
Reaction equation
OC1C=CC(/C=C/C[N:11]2[CH2:16][CH2:15][CH:14]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[CH:19][CH:18]=3)[CH2:13][CH2:12]2)=CC=1OC.Br[CH:33]([CH3:42])[C:34]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)=[O:35]>>[C:34]([CH:33]([N:11]1[CH2:16][CH2:15][CH:14]([C:17]2[CH:18]=[CH:19][C:20]([O:23][C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)=[CH:21][CH:22]=2)[CH2:13][CH2:12]1)[CH3:42])(=[O:35])[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1Participants
3
Procedure
The same procedure was followed as in Example 11 using the compound (9) synthesized in Example 2 and 2-bromopropiophenone to produce the above.
Workup
- customto produce the above
Sources & evidence
- ORD record
- ord-4307f4a2c3cd420aa71c2f79eb3f6507
- Source dataset
- uspto-grants-2000_04
- Patent number
- US06048876
Reaction notes
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