2-Bromo-1-indanone → 4-[4-(4-Fluorophenyl)methylphenyl]-1-(1-oxoindan-2-yl)piperidine

HRID 1004141Notes

Reaction equation

HRID 1004141 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([CH:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.Br[CH:22]1[CH2:30][C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:23]1=[O:31]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([CH:15]3[CH2:16][CH2:17][N:18]([CH:22]4[CH2:30][C:29]5[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=5)[C:23]4=[O:31])[CH2:19][CH2:20]3)=[CH:11][CH:10]=2)=[CH:6][CH:7]=1

Participants

3

Procedure

The same procedure was followed as in Example 11 using the compound (12) synthesized in Example 5 and 2-bromo-1-indanone to produce the above.

Workup

  1. customto produce the above

Sources & evidence

ORD record
ord-6064da116ac1481897394de5b1dfc260
Source dataset
uspto-grants-2000_04
Patent number
US06048876

Reaction notes

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