反应详情

In 200 ml of THF was dissolved 20.5 g of geranylgeranyl bromide, 14.4 ml of piperonylamine was added and stirred at room temperature for one hour. To the reaction mixture was added water and extracted with ethyl acetate. The extract was washed with water and then brine, dried over magnesium sulfate and then concentrated. The concentrate was purified by silica gel column chromatography (using as a developing solvent hexane-ethyl acetate (4:1)→ethyl acetate) to give 17.6 g of N-geranylgeranylpiperonylamine as a yellow liquid.

1. additionwas added
2. extractionextracted with ethyl acetate
3. washThe extract was washed with water
4. dry with materialbrine, dried over magnesium sulfate
5. concentrationconcentrated
6. customThe concentrate was purified by silica gel column chromatography (