反应详情

To a stirred solution of 2,5-dichloro-3-thenoyl chloride (commercially available from Maybridge Chemical Co. Ltd. 1.07 g, 5 mM) in CH2Cl2 (5 mL) was added 40% aqueous solution of methylamine (1 mL) at room temperature. After stirring overnight, the mixture was poured into CH2Cl2 (50 mL). The whole was washed with water (40 mL), brine (40 mL), dried over MgSO4, and concentrated in vacuo. The resulting solid was triturated with Et2O-hexane to give the subtitle compound (0.54 g, 51% yield).

1. washThe whole was washed with water (40 mL), brine (40 mL)
2. dry with materialdried over MgSO4
3. concentrationconcentrated in vacuo
4. customThe resulting solid was triturated with Et2O-hexane