Oxalyl chloride → HCID 18794873, compound

HRID 1004206Notes

Reaction equation

HRID 1004206 reaction equation
[CH3:1][O:2][CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5]1.[C:13](Cl)(=[O:17])[C:14]([Cl:16])=[O:15]>CCOCC>[CH3:1][O:2][CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13](=[O:17])[C:14]([Cl:16])=[O:15])=[CH:5]1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 10491887HCID 10491887, compound

Product 1

HCID 18794873HCID 18794873, compoundYield 48.5%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Using the procedure of Example 1, step B, the reaction of 0.23 g (1.43 mmol) of 1-methoxymethyl-1H-indole (9) from Step A above with 0.25 ml (2.86 mmol) of oxalyl chloride in 3.5 ml of ether produced 0.174 g (48.5%) of (1-methoxymethyl-1H-indol-3-yl)-oxo-acetyl chloride (10) as a yellow solid. This material was used without purification.

Sources & evidence

ORD record
ord-f3b8ecc3718a40fcb69e0d1c3e37d817
Source dataset
uspto-grants-2000_04
Patent number
US06048887

Reaction notes

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