HCID 20691579, compound → HCID 54211117, compound

HRID 1004295Notes

Reaction equation

HRID 1004295 reaction equation
[CH3:1][O:2][C:3](=[O:20])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[CH:19]=[CH:18][C:17]2[C:12](=[N:13][CH:14]=[CH:15][CH:16]=2)[N:11]=1.[H][H]>[Pd].C(O)C>[CH3:1][O:2][C:3](=[O:20])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[CH:19]=[CH:18][C:17]2[CH2:16][CH2:15][CH2:14][NH:13][C:12]=2[N:11]=1

Participants

5

Reactant 2

HCID 20691579HCID 20691579, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 54211117HCID 54211117, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent2×

Procedure

To a stirred suspension of 10% palladium on carbon (600 mg) in ethanol (25 mL) was added a solution of 7-[1,8]naphthyridin-2-yl-heptanoic acid methyl ester 29-3 (3.6 g) in ethanol (75 mL) and the mixture was subjected to an atmosphere of hydrogen for 18 hours. The reaction mixture was filtered through Celite and concentrated at reduced pressure to give 29-4 as an oil.

Workup

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationconcentrated at reduced pressure

Sources & evidence

ORD record
ord-84995f77de4141688d7736368b1f42fb
Source dataset
uspto-grants-2000_04
Patent number
US06048861

Reaction notes

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