Hydrochloric Acid → N-[2-[(Aminothioxomethyl)hydrazono]-2-phenylethyl]acetamide

HRID 1004485Notes

Reaction equation

HRID 1004485 reaction equation
[NH2:1][NH:2][C:3]([NH2:5])=[S:4].O=[C:7]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:8][NH:9][C:10](=[O:12])[CH3:11].Cl.O>CO>[NH2:5][C:3]([NH:2][N:1]=[C:7]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:8][NH:9][C:10](=[O:12])[CH3:11])=[S:4]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 226684n-(2-Oxo-2-phenylethyl)acetamideHCID 2723789Thiosemicarbazide

Product 1

HCID 54251604N-[2-[(Aminothioxomethyl)hydrazono]-2-phenylethyl]acetamideYield 78%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Thiosemicarbazide (1.98 g, 20 mmol) was added to a solution of N-(2-oxo-2-phenyl-ethyl)-acetamide (3.84 g, 20 mmol, prepared in the previous step, in 70 ml of methanol plus 5.4 ml of 1N HCl plus 5.0 ml of water and the reaction stirred at room temperature overnight. The solid formed was collected by filtration and dried to give 3.9 g (78%) of the title compound as a white solid, mp 208-211° C.

Workup

  1. customThe solid formed
  2. filtrationwas collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-d3dc8dc7680d4ea2acf7c93c70220ce4
Source dataset
uspto-grants-2000_04
Patent number
US06049006

Reaction notes

Loading…