7-Aminoheptanoic acid → HCID 86755329, compound

HRID 1004528Notes

Reaction equation

HRID 1004528 reaction equation
N[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=[O:9].[C:11]([CH2:14][NH:15][C:16]1[C:17]([I:32])=[C:18]([C:29](Cl)=[O:30])[C:19]([I:28])=[C:20]([NH:23][CH2:24][C:25](=[O:27])[CH3:26])[C:21]=1[I:22])(=[O:13])[CH3:12].CC([N:36](C)C)=O>>[C:11]([CH2:14][NH:15][C:16]1[C:17]([I:32])=[C:18]([C:29]([NH:36][CH:5]([CH2:4][CH2:3][CH3:2])[CH2:6][CH2:7][C:8]([OH:10])=[O:9])=[O:30])[C:19]([I:28])=[C:20]([NH:23][CH2:24][C:25](=[O:27])[CH3:26])[C:21]=1[I:22])(=[O:13])[CH3:12]

Participants

4

Reactant 3

HCID 135807-Aminoheptanoic acidHCID 31374DimethylacetamideHCID 21715954HCID 21715954, compound

Product 1

HCID 86755329HCID 86755329, compound

Conditions

Temperature
80 °C

Procedure

To a solution of 7-aminoheptanoic acid (0.8 g, 5.5 mmol) in DMA (20 mL) was added MDTA-Cl (X) (2.8 g, 4.2 mmol) and the mixture stirred at 80° C. for 24 h. DMA was removed. To the residue water was added. The solid material was collected and recrystallized from EtOH to furnish the pure title compound XIIIc (1.02 g, 31%).

Workup

  1. customDMA was removed
  2. additionTo the residue water was added
  3. customThe solid material was collected
  4. customrecrystallized from EtOH

Sources & evidence

ORD record
ord-56d07a7f7658417d832fb7b648a14cf9
Source dataset
uspto-grants-2000_04
Patent number
US06051210

Reaction notes

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