5-[3-(Benzyloxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine → HCID 44381608, compound

HRID 1004606Notes

Reaction equation

HRID 1004606 reaction equation
C(OC1C=CC(C2C3C(N)=NC=NC=3NC=2)=CC=1)C1C=CC=CC=1.[CH2:25]([O:32][C:33]1[CH:34]=[C:35]([C:39]2[C:47]3[C:46]([NH2:48])=[N:45][CH:44]=[N:43][C:42]=3[NH:41][CH:40]=2)[CH:36]=[CH:37][CH:38]=1)C1C=CC=CC=1.[C:49]([O:53][C:54]([N:56]1[CH2:60][CH2:59][CH:58](CS(C2C=CC(C)=CC=2)(=O)=O)[CH2:57]1)=[O:55])([CH3:52])([CH3:51])[CH3:50]>>[C:49]([O:53][C:54]([N:56]1[CH2:60][CH2:59][CH:58]([N:41]2[C:42]3[N:43]=[CH:44][N:45]=[C:46]([NH2:48])[C:47]=3[C:39]([C:35]3[CH:36]=[CH:37][CH:38]=[C:33]([O:32][CH3:25])[CH:34]=3)=[CH:40]2)[CH2:57]1)=[O:55])([CH3:52])([CH3:50])[CH3:51]

Participants

4

Reactant 3

HCID 187928915-[3-(Benzyloxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amineHCID 227361705-(4-benzyloxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamineHCID 537185573-(Toluene-4-sulfonylmethyl)-pyrrolidine-carboxylic acid tert-butyl ester

Product 1

HCID 44381608HCID 44381608, compound

Procedure

Examples 63 and 64 are prepared analogously to Example 20/21 starting from 5-(4-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl-amine or 5-(3-benzyloxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl-amine and 3-(toluene-4-sulfonylmethyl)-pyrrolidine-carboxylic acid tert-butyl ester.

Sources & evidence

ORD record
ord-391884e8904b493882ac2a1d5afb30a9
Source dataset
uspto-grants-2000_04
Patent number
US06051577

Reaction notes

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