Hydrogen Bromide → HCID 86755333, compound

HRID 1004618Notes

Reaction equation

HRID 1004618 reaction equation
C[O:2][C:3]1[C:15]2[CH2:14][C@H:13]3[C@H:9]([CH2:10][CH2:11][NH:12]3)[CH2:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.[BrH:16]>O>[BrH:16].[OH:2][C:3]1[C:15]2[CH2:14][C@H:13]3[C@H:9]([CH2:10][CH2:11][NH:12]3)[CH2:8][C:7]=2[CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 86755331HCID 86755331, compound

Product 1

HCID 86755333HCID 86755333, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.55 g (2.7 mmol) of cis-(±)-8-methoxy-2,3,3a,4,9,9a-hexahydro-1H-benz[f]indole (10b) are added to 6 mL of water and 12 mL of conc. hydrobromic acid and refluxed for 20 h . Then the mixture is concentrated by evaporation in vacuo, the residue is taken up again in 10 mL of ethanol and the solvent is eliminated again in vacuo. 0.69 g (95%) of the desired product are obtained as the hydrobromide.

Workup

  1. temperaturerefluxed for 20 h
  2. concentrationThen the mixture is concentrated by evaporation in vacuo

Sources & evidence

ORD record
ord-8ac7831afaf648a6a3eabc0566e0f62e
Source dataset
uspto-grants-2000_04
Patent number
US06051583

Reaction notes

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