反应详情

A solution of 3-phenoxy-1-propanamine (24.2 g, 160 mmol) in 100 mL of 2-propanol is heated to reflux and treated slowly with a solution of 4-(2-bromoethoxy)phenol (17.4 g, 80 mmol) in 150 mL of 2-propanol. The mixture is heated at reflux for 4 days, then cooled and partitioned between ethyl ether and aqueous sodium bicarbonate solution. The organic layer is evaporated and the residue recrystallized from ethanol to give 6.0 g (20%) of product, mp 204-205° C.

1. temperatureto reflux
2. temperatureThe mixture is heated
3. temperatureat reflux for 4 days
4. temperaturecooled
5. custompartitioned between ethyl ether and aqueous sodium bicarbonate solution
6. customThe organic layer is evaporated
7. customthe residue recrystallized from ethanol