反应详情

温度

100 °C

Iron powder (5 g) was added in one portion to 9.8 g of 2'-methoxy-3-nitrobiphenyl-4-acetic acid in 50 mL of glacial acetic acid was heated to 100° C. for 3 hours. The reaction mixture was concentrated to dryness, sonicated in ethyl acetate and filtered to remove the insolubles. The filtrate was washed twice with 1 N hydrochloric acid, water and then brine, dried over anhydrous sodium sulfate and concentrated. The residue was chromatographed on silica gel in ethyl acetate:hexane (1:2) to give 5.4 g of 6-(2-methoxyphenyl)-2-oxindole as a rose colored solid.

1. concentrationThe reaction mixture was concentrated to dryness
2. customsonicated in ethyl acetate
3. filtrationfiltered
4. customto remove the insolubles
5. washThe filtrate was washed twice with 1 N hydrochloric acid, water
6. dry with materialbrine, dried over anhydrous sodium sulfate
7. concentrationconcentrated
8. customThe residue was chromatographed on silica gel in ethyl acetate:hexane (1:2)