反应详情

Iron powder (2.4 g) was added in one portion to 4.6 g of 3'-ethoxy-3-nitrobiphenyl-4-acetic acid in 40 mL of glacial acetic acid and refluxed for 2 hours. The reaction mixture was concentrated to dryness, treated repeatedly with ethyl acetate and filtered to remove the insolubles. The filtrate was washed twice with 1 N hydrochloric acid and brine and then dried over anhydrous sodium sulfate and concentrated to give 3.5 g (91% yield) of 6-(3-ethoxyphenyl)-2-oxindole as a light brown solid.

1. temperaturerefluxed for 2 hours
2. concentrationThe reaction mixture was concentrated to dryness
3. additiontreated repeatedly with ethyl acetate
4. filtrationfiltered
5. customto remove the insolubles
6. washThe filtrate was washed twice with 1 N hydrochloric acid and brine
7. dry with materialdried over anhydrous sodium sulfate
8. concentrationconcentrated