反应详情

温度

110 °C

36.8 g (184.1 mmols) of N-ethyl-4-bromoaniline, 48.1 ml (1.5-fold equivalent weight) of N,N-diisopropylethylamine and 28.9 ml (1.2 equivalent) of 6-bromohexanol were mixed, and the mixture obtained was heated at 110° C. for 14 hours in an atmosphere of argon. Water was added to the reaction solution obtained, which was then extracted with ethyl acetate. The organic layer obtained was dried with anhydrous magnesium sulfate and then concentrated. The residue thus obtained was heated under reduced pressure (160° C./0.3 torr), and the components distilled out were removed to obtain 55.6 g of crude N-ethyl-N-(6-hydroxyhexyl)-4-bromoaniline (yield: 100%; a dark-brown oily liquid).

1. customthe mixture obtained
2. customobtained
3. extractionwhich was then extracted with ethyl acetate
4. customThe organic layer obtained
5. dry with materialwas dried with anhydrous magnesium sulfate
6. concentrationconcentrated
7. customThe residue thus obtained
8. temperaturewas heated under reduced pressure (160° C./0.3 torr)
9. distillationthe components distilled out
10. customwere removed