2-(Bromomethyl)benzonitrile → HCID 53718569, compound

HRID 1004955Notes

Reaction equation

HRID 1004955 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]3[CH2:15][CH2:14][N:13]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:12][CH:11]3[O:23][CH2:24][C:25]3[CH:34]=[CH:33][C:32]4[C:27](=CC=CC=4)[CH:26]=3)=[CH:9][C:4]=2[O:3][CH2:2]1.BrCC1C=CC=CC=1[C:39]#[N:40]>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]3[CH2:15][CH2:14][N:13]([C:16]([O:18][C:19]([CH3:21])([CH3:22])[CH3:20])=[O:17])[CH2:12][CH:11]3[O:23][CH2:24][C:25]3[CH:26]=[CH:27][CH:32]=[CH:33][C:34]=3[C:39]#[N:40])=[CH:9][C:4]=2[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 895992-(Bromomethyl)benzonitrileHCID 53909146HCID 53909146, compound

Product 1

HCID 53718569HCID 53718569, compound

Procedure

In an analogous manner to that described in Example 1(g), by alkylating tert-butyl (3RS,4RS)-4-benzo[1,3]dioxol-5-yl-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylate [Example 8(f)] with 2-bromomethyl-benzonitrile there was obtained tert-butyl (3RS,4RS)-4-benzo[1,3]dioxol-5-yl-3-(2-cyano-benzyloxy)-piperidine-1-carboxylate as colourless crystals; MS: 455 (M+H)+.

Sources & evidence

ORD record
ord-87744914da6f4655b821be13ec51fc12
Source dataset
uspto-grants-2000_04
Patent number
US06051712

Reaction notes

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