HRID1004993

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID70320

2-Bromomethylnaphthalene

C11H9Br

结构：CCOC(=O)C=Cc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2O)cc1

HCID86604399

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C=Cc1ccc(C2CCN(C(=O)OC(C)(C)C)CC2OCc2ccc3ccccc3c2)cc1

HCID53757216

未命名化合物

PROCEDURE

实验过程

Alkylation of tert-butyl (3 RS,4RS)-4-[4-(2-ethoxycarbonyl-vinyl)-phenyl]-3-hydroxy-piperidine-1-carboxylate with 2-bromomethyinaphthalene analogously to the procedure described in Example 22(i) gave tert-butyl (3RS,4RS)-4-[4-(2-ethoxycarbonyl-vinyl)-phenyl]-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylate as a light yellow resin; MS: 516 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1114b126de2b45379706f3e8c776710e
来源数据集: uspto-grants-2000_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06051712
来源说明: uspto-grants-2000_04

反应 SMILES

[CH2:1]([O:3][C:4]([CH:6]=[CH:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[CH2:19][CH2:18][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:16][CH:15]2[OH:27])=[CH:10][CH:9]=1)=[O:5])[CH3:2].Br[CH2:29][C:30]1[CH:39]=[CH:38][C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH:31]=1>>[CH2:1]([O:3][C:4]([CH:6]=[CH:7][C:8]1[CH:9]=[CH:10][C:11]([CH:14]2[CH2:19][CH2:18][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:16][CH:15]2[O:27][CH2:29][C:30]2[CH:39]=[CH:38][C:37]3[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=3)[CH:31]=2)=[CH:12][CH:13]=1)=[O:5])[CH3:2]