HRID1005080

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10910168

2-(TRIMETHYLSILYL)ETHYL CHLOROFORMATE

C6H13ClO2Si

反应SMILES：CCCC1CN(Cc2ccccc2)CC(OCc2cc(OCc3ccccc3)c3ccccc3c2)C1c1ccc(F)cc1

HCID22128736

未命名化合物

PRODUCTS

产物

反应SMILES：CCCC1CN(C(=O)OCC[Si](C)(C)C)CC(OCc2cc(OCc3ccccc3)c3ccccc3c2)C1c1ccc(F)cc1

HCID86604430

未命名化合物

PROCEDURE

实验过程

In an analogous manner to that described in Example 1(d), by reacting (3RS,4RS,5SR)-1-benzyl-3-(4-benzyloxy-naphthalen-2-ylmethoxy)-4-(4-fluoro-phenyl)-5-propyl-piperidine with β-trimethylsilylethyl chloroformate [Synthesis 346 (1987)] there was obtained 2-trimethylsilanylethyl (3RS,4RS,5SR)-3-(4-benzyloxy-naphthalen-2-ylmethoxy)-4-(4-fluoro-phenyl)-5-propyl-piperidine-1-carboxylate as a pale yellow syrup, MS: 628 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-e56aebe68a5d4925b93a1a69faa6b0ef
来源数据集: uspto-grants-2000_04
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US06051712
来源说明: uspto-grants-2000_04

反应SMILES

C([N:8]1[CH2:13][CH:12]([CH2:14][CH2:15][CH3:16])[CH:11]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)[CH:10]([O:24][CH2:25][C:26]2[CH:35]=[C:34]([O:36][CH2:37][C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)[C:33]3[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH:27]=2)[CH2:9]1)C1C=CC=CC=1.Cl[C:45]([O:47][CH2:48][CH2:49][Si:50]([CH3:53])([CH3:52])[CH3:51])=[O:46]>>[CH2:37]([O:36][C:34]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:27]=[C:26]([CH2:25][O:24][CH:10]2[CH:11]([C:17]3[CH:18]=[CH:19][C:20]([F:23])=[CH:21][CH:22]=3)[CH:12]([CH2:14][CH2:15][CH3:16])[CH2:13][N:8]([C:45]([O:47][CH2:48][CH2:49][Si:50]([CH3:53])([CH3:52])[CH3:51])=[O:46])[CH2:9]2)[CH:35]=1)[C:38]1[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1