反应详情

温度

0 °C

9 g (27 mmol) of 3-(4-chlorophenyl)-1-methyl-4,5-di(trifluoromethyl)-1H-pyrazole were added at (-40)° C. to 100 ml of concentrated nitric acid, whereupon the mixture was stirred for 2 hours at this temperature. The solution, which was subsequently warmed to 0° C., was treated with ice-water. The product was subsequently extracted with methyl tert-butyl ether. The organic phase was washed with water, dried over magnesium sulfate and concentrated.

1. extractionThe product was subsequently extracted with methyl tert-butyl ether
2. washThe organic phase was washed with water
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated