Nitric Acid → 3-(4-Chloro-3-nitrophenyl)-1-methyl-4,5-di(trifluoromethyl)-1H-pyrazole

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Reaction Conditions

Reaction Steps

9 g (27 mmol) of 3-(4-chlorophenyl)-1-methyl-4,5-di(trifluoromethyl)-1H-pyrazole were added at (-40)° C. to 100 ml of concentrated nitric acid, whereupon the mixture was stirred for 2 hours at this temperature. The solution, which was subsequently warmed to 0° C., was treated with ice-water. The product was subsequently extracted with methyl tert-butyl ether. The organic phase was washed with water, dried over magnesium sulfate and concentrated.

Provenance & Evidence