Nitric Acid → HCID 18791018, compound

HRID 1005281Notes

Reaction equation

HRID 1005281 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]([F:16])([F:15])[F:14])=[C:11]([C:17]([F:20])([F:19])[F:18])[N:10]([CH3:21])[N:9]=2)=[C:4]([F:22])[CH:3]=1.[N+:23]([O-])([OH:25])=[O:24]>>[Cl:1][C:2]1[C:7]([N+:23]([O-:25])=[O:24])=[CH:6][C:5]([C:8]2[C:12]([C:13]([F:16])([F:14])[F:15])=[C:11]([C:17]([F:18])([F:19])[F:20])[N:10]([CH3:21])[N:9]=2)=[C:4]([F:22])[CH:3]=1

Participants

3

Reactant 2

HCID 944Nitric AcidHCID 18791016HCID 18791016, compound

Product 1

HCID 18791018HCID 18791018, compoundYield 59%

Procedure

10.5 g (30 mmol) of 3-(4-chloro-2-fluorophenyl)-l-methyl-4,5-di(trifluoromethyl)-1H-pyrazole were added, at (-40)° C. to 90 ml of concentrated nitric acid, whereupon the mixture was stirred for 1 hour. Then, the mixture was stirred in 0.8 1 of ice-water. The product of value was subsequently extracted with dichloromethane. The organic phase was dried over magnesium sulfate and finally concentrated. Yield: 59%.

Workup

  1. extractionThe product of value was subsequently extracted with dichloromethane
  2. dry with materialThe organic phase was dried over magnesium sulfate
  3. concentrationfinally concentrated

Sources & evidence

ORD record
ord-506200c80c6445ef9a0a9555e12fc3f6
Source dataset
uspto-grants-2000_04
Patent number
US06054412

Reaction notes

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