Nitric Acid → HCID 18791018, compound

Participants

Reaction Steps

10.5 g (30 mmol) of 3-(4-chloro-2-fluorophenyl)-l-methyl-4,5-di(trifluoromethyl)-1H-pyrazole were added, at (-40)° C. to 90 ml of concentrated nitric acid, whereupon the mixture was stirred for 1 hour. Then, the mixture was stirred in 0.8 1 of ice-water. The product of value was subsequently extracted with dichloromethane. The organic phase was dried over magnesium sulfate and finally concentrated. Yield: 59%.

Provenance & Evidence