反应详情

8.4 g (0.033 mol) of 4-ethoxy-8-methylthiochroman-7-carboxylic acid are initially introduced in 60 ml of acetic acid. A spatula tipful of sodium tungstate is added. 7.9 g (0.07 mol) is of 30% strength hydrogen peroxide solution are slowly added dropwise at 50° C. and the reaction mixture is subsequently stirred for 2 hours. It is then poured into water and the aqueous phase is extracted with ethyl acetate. The organic phase is washed with bisulfite solution, then dried and concentrated.

1. additionare slowly added dropwise at 50° C.
2. extractionthe aqueous phase is extracted with ethyl acetate
3. washThe organic phase is washed with bisulfite solution
4. customdried
5. concentrationconcentrated