HCID 18791148, compound → HCID 18791127, compound

HRID 1005335Notes

Reaction equation

HRID 1005335 reaction equation
[CH:1]([NH:3][C:4](=[C:9]1[CH2:12][C:11]([C:18]([O:20][CH2:21][CH3:22])=[O:19])([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:10]1)[C:5]([O:7][CH3:8])=[O:6])=[O:2]>C(O)C.[C].[Pd]>[CH3:8][O:7][C:5](=[O:6])[CH:4]([CH:9]1[CH2:10][C:11]([C:13]([O:15][CH2:16][CH3:17])=[O:14])([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH2:12]1)[NH:3][CH:1]=[O:2]

Participants

4

Reactant 1

HCID 18791148HCID 18791148, compound

Product 1

HCID 18791127HCID 18791127, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

A solution of methyl N-formyl-α-(3,3-diethoxycarbonylcyclobutylidene)glycinate (0.46 g, 1.47 mmol) in ethanol (40 ml) was hydrogenated over 10% palladium-carbon (100 mg) at 65 psi for 24 hours. The reaction mixture was filtered through a pad of celite and evaporated to give a yellow oil.

Workup

  1. filtrationThe reaction mixture was filtered through a pad of celite
  2. customevaporated
  3. customto give a yellow oil

Sources & evidence

ORD record
ord-51bc421d419f40ceaa2828a45a2e222c
Source dataset
uspto-grants-2000_04
Patent number
US06054448

Reaction notes

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