HCID 18791134, compound → HCID 18791114, compound

HRID 1005338Notes

Reaction equation

C([O:3][C:4]([C:6]1([C:31]([O:33]CC)=[O:32])[CH2:9][CH:8]([C:10]2([CH2:17][CH:18]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[NH:14][C:13](=[O:15])[NH:12][C:11]2=[O:16])[CH2:7]1)=[O:5])C>[OH-].[Na+]>[C:4]([C:6]1([C:31]([OH:33])=[O:32])[CH2:9][CH:8]([C:10]2([CH2:17][CH:18]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[NH:14][C:13](=[O:15])[NH:12][C:11]2=[O:16])[CH2:7]1)([OH:5])=[O:3]

Participants

Conditions

Temperature: 70 °C

Procedure

A stirred mixture of 5-[3,3-di(ethoxycarbonyl) cyclobutyl]-5-(2,2-diphenylethyl)imidazolidine-2,4-dione (1.7 mmol) in 1M sodium hydroxide (17 ml) was heated to 70° C. for 2 hours. The cooled solution was filtered and the filtrate acidified with 5M hydrochloric acid (4 ml). The mixture was extracted with diethyl ether (30 ml) ethanol (3 ml) to give the title product as a white foam.

Workup

filtrationThe cooled solution was filtered
extractionThe mixture was extracted with diethyl ether (30 ml) ethanol (3 ml)

Sources & evidence

ORD record: ord-07f1b82e34254a2592c40db5116aaace
Source dataset: uspto-grants-2000_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06054448

Reaction notes

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