Piperidine → HCID 136333570, compound

HRID 1005362Notes

Reaction equation

HRID 1005362 reaction equation
C([NH:18][C@H:19]([C:25]([C@@:27]1([N:36]2[C:46]3[N:45]=[C:43]([NH2:44])[NH:42][C:40](=[O:41])[C:39]=3[N:38]=[CH:37]2)[O:35][C@H:32]([CH2:33][OH:34])[C@@H:30]([OH:31])[C@H:28]1[OH:29])=[O:26])[CH2:20][CH2:21][CH2:22][CH2:23][NH2:24])(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O.N1CCCCC1>N1C=CC=CC=1>[NH2:18][C@H:19]([C:25]([C@@:27]1([N:36]2[C:46]3[N:45]=[C:43]([NH2:44])[NH:42][C:40](=[O:41])[C:39]=3[N:38]=[CH:37]2)[O:35][C@H:32]([CH2:33][OH:34])[C@@H:30]([OH:31])[C@H:28]1[OH:29])=[O:26])[CH2:20][CH2:21][CH2:22][CH2:23][NH2:24]

Participants

4

Reactant 2

HCID 8082PiperidineHCID 136341909HCID 136341909, compound

Product 1

HCID 136333570HCID 136333570, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
0 °C

Procedure

To a stirred solution of 800 mg of (Nα-FMOC-lysyl)guanosine in anhydrous pyridine was added anhydrous piperidine (4 mol eq.). The mixture was allowed to stir for 5 hr at 0° C. and then was evaporated to dryness. The residue was dissolved in DMF and purified by slow addition of the DMF solution to a rapidly stirred solution of EtOH-Et2O, yielding a precipitate.

Workup

  1. customwas evaporated to dryness
  2. dissolutionThe residue was dissolved in DMF
  3. custompurified by slow addition of the DMF solution to a rapidly stirred solution of EtOH-Et2O
  4. customyielding a precipitate

Sources & evidence

ORD record
ord-8f7c1bb290fe45bd82b220c3c32891a5
Source dataset
uspto-grants-2000_04
Patent number
US06054441

Reaction notes

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