Trifluoroacetic acid → HCID 86755345, compound

HRID 1005381Notes

Reaction equation

HRID 1005381 reaction equation
C(OC([N:8]1[C:12]2[CH2:13][C@H:14]([C:30](=[O:48])[NH:31][CH2:32][CH2:33][C:34]3[N:35]([CH2:39][C:40]4[CH:45]=[CH:44][C:43]([C:46]#[N:47])=[CH:42][CH:41]=4)[CH:36]=[N:37][CH:38]=3)[CH:15](C(OC(C)(C)C)=O)[N:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:11]=2[N:10]=[CH:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:46]([C:43]1[CH:42]=[CH:41][C:40]([CH2:39][N:35]2[C:34]([CH2:33][CH2:32][NH:31][C:30]([C@H:14]3[CH2:13][C:12]4[NH:8][CH:9]=[N:10][C:11]=4[N:16]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[CH2:15]3)=[O:48])=[CH:38][N:37]=[CH:36]2)=[CH:45][CH:44]=1)#[N:47]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86755342HCID 86755342, compound

Product 1

HCID 86755345HCID 86755345, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 6(S)-{2-[3-(4-cyano-benzyl)-3H-imidazol-4yl]ethylcarbamoyl}-4-phenyl-6,7-dihydro-4H-imidazo [4,5-]pyridine-1,5-dicarboxylic acid di-tert-butyl ester (0.58 g) in CH2Cl2 (10 ml) was added TFA (5 ml) and the solution was stirred 45 min. The solvents were removed in vacuo and the crude product was purified by preparative HPLC to obtain diastereomer A and diastereomer B as the title compounds.

Workup

  1. customThe solvents were removed in vacuo
  2. customthe crude product was purified by preparative HPLC

Sources & evidence

ORD record
ord-a5f201335910441786db901799b0c917
Source dataset
uspto-grants-2000_04
Patent number
US06054466

Reaction notes

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