HCID 21706541, compound → HCID 21706524, compound

HRID 1005420Notes

Reaction equation

HRID 1005420 reaction equation
C(OC([NH:11][C:12]1[C:13](=[O:28])[N:14]([CH2:19][C:20]2[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=2)[N:15]=[CH:16][C:17]=1[CH3:18])=O)C1C=CC=CC=1>C(O)C.C(OCC)(=O)C.[Pd]>[NH2:11][C:12]1[C:13](=[O:28])[N:14]([CH2:19][C:20]2[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=2)[N:15]=[CH:16][C:17]=1[CH3:18]

Participants

5

Reactant 1

HCID 21706541HCID 21706541, compound

Product 1

HCID 21706524HCID 21706524, compoundYield 910%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 4-benzyloxycarbonylamino-2-(4-methoxybenzyl)-5-methyl-3-pyridazinone (0.39 g, 1.0 mmol) and 10% Pd/C (0.10 g) in ethanol (40 mL) and ethyl acetate (5 mL) was hydrogenated at 45 psi in a Parr apparatus for 1.3 hours. The catalyst was removed by filtration and the solvents were evaporated to give 4-amino-2-(4-methoxybenzyl)-5-methyl-3-pyridazinone (0.23 g, 1.0 mmol, 910%).

Workup

  1. customThe catalyst was removed by filtration
  2. customthe solvents were evaporated

Sources & evidence

ORD record
ord-ba253be7507b458e988fc9aa1910ea28
Source dataset
uspto-grants-2000_04
Patent number
US06054470

Reaction notes

Loading…