2-[5-(3,5-Dimethyl-phenylsulfanyl)-4-isopropyl-2-methyl-imidazol-1-ylmethoxy]-ethanol → HCID 17776718, compound

HRID 1005509Notes

Reaction equation

HRID 1005509 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([S:9][C:10]2[N:14]([CH2:15][O:16][CH2:17][CH2:18][OH:19])[C:13]([CH3:20])=[N:12][C:11]=2[CH:21]([CH3:23])[CH3:22])[CH:5]=[C:6]([CH3:8])[CH:7]=1.CO[C:26]1[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH:27]=1>>[C:26]1([O:19][CH2:18][CH2:17][O:16][CH2:15][N:14]2[C:10]([S:9][C:4]3[CH:3]=[C:2]([CH3:1])[CH:7]=[C:6]([CH3:8])[CH:5]=3)=[C:11]([CH:21]([CH3:23])[CH3:22])[N:12]=[C:13]2[CH3:20])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH:27]=1

Participants

3

Reactant 2

HCID 4781802-[5-(3,5-Dimethyl-phenylsulfanyl)-4-isopropyl-2-methyl-imidazol-1-ylmethoxy]-ethanolHCID 110298511-methoxycycloheptene

Product 1

HCID 17776718HCID 17776718, compoundYield 77%

Procedure

The compound 1 (401 mg, 1.20 mmol) was converted to the enol ether with 1-methoxy-1-cycloheptene (1.51 g, 12.0 mmol) in the same manner as the example 7 to give the compound 7 (372 mg, 77%) as oil. Rf 0.75 (Al2O3 60-type E, 2:1 hexane -EtOAc).

Sources & evidence

ORD record
ord-75f81a0568c84c17b2e6504481baf651
Source dataset
uspto-grants-2000_04
Patent number
US06054591

Reaction notes

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