Hydrochloric Acid → HCID 86585566, compound

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Reaction Steps

The compound was prepared by coupling of 1,1'-carbonyldimmidazole with 1-[(3,4-dichlorophenyl)acetyl]-2-(R)-[(1-pyrrolidinyl)methyl]piperazine; mp: (HCl salt) 148° C. (dec.); 1H NMR (free base, 200 MHz, CDCl3) δ1.5-1.7 (4 H, m), 2.1-2.5 (5 H, m), 2.6-3.4 (4 H, m), 3.5-4.8 (7 H, m), 6.9-7.4 (4 H, m), 8.0 (1 H, m); MS (FAB) 450 (M+H)+ ; Anal. Calcd for C21H25Cl2N5O2.2HCl. H2O: C, 46.60; H, 5.40; N, 12.94. Found: C, 45.41; H, 5.33; N, 12.73

Provenance & Evidence