Hydrochloric Acid → HCID 86585566, compound

HRID 1005572Notes

Reaction equation

HRID 1005572 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][C@@H:13]2[CH2:18][N:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.[OH2:25]>>[C:18](=[C:13]1[CH:14]=[N:15][CH:17]=[N:12]1)=[O:25].[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][C@@H:13]2[CH2:18][N:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 21336729HCID 21336729, compound

Product 1

HCID 86585566HCID 86585566, compound

Procedure

The compound was prepared by coupling of 1,1'-carbonyldimmidazole with 1-[(3,4-dichlorophenyl)acetyl]-2-(R)-[(1-pyrrolidinyl)methyl]piperazine; mp: (HCl salt) 148° C. (dec.); 1H NMR (free base, 200 MHz, CDCl3) δ1.5-1.7 (4 H, m), 2.1-2.5 (5 H, m), 2.6-3.4 (4 H, m), 3.5-4.8 (7 H, m), 6.9-7.4 (4 H, m), 8.0 (1 H, m); MS (FAB) 450 (M+H)+ ; Anal. Calcd for C21H25Cl2N5O2.2HCl. H2O: C, 46.60; H, 5.40; N, 12.94. Found: C, 45.41; H, 5.33; N, 12.73

Sources & evidence

ORD record
ord-2d290b3bc6b945e780d80a7a5913f909
Source dataset
uspto-grants-2000_04
Patent number
US06054445

Reaction notes

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