Hydrochloric Acid → HCID 18791194, compound

Participants

Reaction Steps

To a solution of 4-[2-[(3-aminoprop-1-yl)oxy]benzoyl]amino-N-methyl-N-[2-[5-(4-methylpiperazin-1-yl)carbonylpent-1-yloxy]phenyl]benzamide (250 mg) was added 4 N hydrogen chloride in ethyl acetate (1 ml) and the solution was stirred at ambient temperature for 10 minutes. The white solid was filtered and dried under reduced pressure to give 4-[2-[(3-aminoprop-1-yl)oxy]benzoyl]amino-N-methyl-N-[2-[5-(4-methylpiperazin-1-yl)carbonylpent-1-yloxy]phenyl]benzamide dihydrochloride (205 mg) as a white powder.

Provenance & Evidence