Hydrochloric Acid → HCID 18791194, compound

HRID 1005591Notes

Reaction equation

HRID 1005591 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:45]=[CH:44][CH:43]=[CH:42][C:7]=1[C:8]([NH:10][C:11]1[CH:41]=[CH:40][C:14]([C:15]([N:17]([CH3:39])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]([N:32]2[CH2:37][CH2:36][N:35]([CH3:38])[CH2:34][CH2:33]2)=[O:31])=[O:16])=[CH:13][CH:12]=1)=[O:9].[ClH:46]>C(OCC)(=O)C>[ClH:46].[ClH:46].[NH2:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:45]=[CH:44][CH:43]=[CH:42][C:7]=1[C:8]([NH:10][C:11]1[CH:41]=[CH:40][C:14]([C:15]([N:17]([CH3:39])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]([N:32]2[CH2:33][CH2:34][N:35]([CH3:38])[CH2:36][CH2:37]2)=[O:31])=[O:16])=[CH:13][CH:12]=1)=[O:9]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11104071HCID 11104071, compound

Product 1

HCID 18791194HCID 18791194, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 4-[2-[(3-aminoprop-1-yl)oxy]benzoyl]amino-N-methyl-N-[2-[5-(4-methylpiperazin-1-yl)carbonylpent-1-yloxy]phenyl]benzamide (250 mg) was added 4 N hydrogen chloride in ethyl acetate (1 ml) and the solution was stirred at ambient temperature for 10 minutes. The white solid was filtered and dried under reduced pressure to give 4-[2-[(3-aminoprop-1-yl)oxy]benzoyl]amino-N-methyl-N-[2-[5-(4-methylpiperazin-1-yl)carbonylpent-1-yloxy]phenyl]benzamide dihydrochloride (205 mg) as a white powder.

Workup

  1. filtrationThe white solid was filtered
  2. customdried under reduced pressure

Sources & evidence

ORD record
ord-8bffdb762cbc4855a2e0828efbc298ed
Source dataset
uspto-grants-2000_04
Patent number
US06054457

Reaction notes

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