反应详情

A mixture of 2-aminothieno[3,2-d]pyrimidin-4-yl 2-thienylmethanone (0.07 g, 0.27 mmol), anhydrous pyridine (3 mL) and acetyl chloride (0.15 g, 1.88 mmol) was refluxed for 24 h, cooled to room temperature, poured into water (30 mL) and extracted with EtOAc (2×30 mL). The organic phase was washed with 1-M HCl (2×25 mL) and saturated brine (25 mL), dried (MgSO4) and concentrated in vacuo to give a yellow solid which was purified by chromatography (SiO2; heptane-EtOAc (2:1)] to give the title compound (50 mg, 58%) as a yellow solid.

1. temperaturewas refluxed for 24 h
2. extractionextracted with EtOAc (2×30 mL)
3. washThe organic phase was washed with 1-M HCl (2×25 mL) and saturated brine (25 mL)
4. dry with materialdried (MgSO4)
5. concentrationconcentrated in vacuo
6. customto give a yellow solid which
7. customwas purified by chromatography (SiO2