Ammonia → 6-Amino-3-methoxy-2-pyrazinecarboxamide

HRID 1005732Notes

Reaction equation

HRID 1005732 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8](OC)=[O:9])[C:5]([O:12][CH3:13])=[N:4][CH:3]=1.[NH3:14]>CO>[NH2:1][C:2]1[N:7]=[C:6]([C:8]([NH2:14])=[O:9])[C:5]([O:12][CH3:13])=[N:4][CH:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 22662843Methyl 6-amino-3-methoxy-2-pyrazinecarboxylate

Product 1

HCID 226628026-Amino-3-methoxy-2-pyrazinecarboxamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 70 mL of methanol is dissolved 3.50 g of methyl 6-amino-3-methoxy-2-pyrazinecarboxylate. Gaseous ammonia is introduced to saturate the solution with ammonia. The solution is stirred at ambient temperature for 14 hours. The solvent is distilled off from the reaction mixture under reduced pressure to obtain 3.1 g of 6-amino-3-methoxy-2-pyrazinecarboxamide.

Workup

  1. concentrationto saturate the solution with ammonia
  2. distillationThe solvent is distilled off from the reaction mixture under reduced pressure

Sources & evidence

ORD record
ord-8945073da1d74c91b7401f03e7d09e37
Source dataset
uspto-grants-2004_09
Patent number
US06787544B2

Reaction notes

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