HCID 12571053, compound → HCID 178513806, compound

HRID 1005741Notes

Reaction equation

HRID 1005741 reaction equation
C[O:2][C:3]1[C:4]([C:10]([NH2:12])=[O:11])=[N:5][CH:6]=[CH:7][N+:8]=1[O-:9]>Br>[OH:2][C:3]1[C:4]([C:10]([NH2:12])=[O:11])=[N:5][CH:6]=[CH:7][N+:8]=1[O-:9]

Participants

3

Reactant 1

HCID 12571053HCID 12571053, compound

Product 1

HCID 178513806HCID 178513806, compoundYield 65.4%

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Conditions

Temperature
45 °C

Procedure

In 0.5 mL of 47% aqueous solution of hydrogen bromide is dissolved 0.05 g of 3-methoxy-2-pyrazinecarboxamide-4-oxide obtained according to the method described in literature [Eur. J. Med. Chem., 15(2), 157-163 (1980)]. The solution is stirred at 45° C. for 2 hours. The deposited crystals are collected by filtration and washed successively with ethanol and diethyl ether to obtain 0.03 g of 3-hydroxy-2-pyrazinecarboxamide-4-oxide.

Workup

  1. customobtained
  2. filtrationThe deposited crystals are collected by filtration
  3. washwashed successively with ethanol and diethyl ether

Sources & evidence

ORD record
ord-6151f144e4ed4d3183e1870be96eb202
Source dataset
uspto-grants-2004_09
Patent number
US06787544B2

Reaction notes

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