Hydrochloric Acid → HCID 178513809, compound

HRID 1005747Notes

Reaction equation

HRID 1005747 reaction equation
[OH:1][C:2]1[C:3]([C:14]([NH2:16])=[O:15])=[N:4][C:5]([C:9]([O:11]CC)=[O:10])=[C:6]([OH:8])[N:7]=1.[OH-].[Na+].Cl>O.C(O)C>[OH:1][C:2]1[C:3]([C:14]([NH2:16])=[O:15])=[N:4][C:5]([C:9]([OH:11])=[O:10])=[C:6]([OH:8])[N:7]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178470256HCID 178470256, compound

Product 1

HCID 178513809HCID 178513809, compoundYield 61.4%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

In a mixture of 1.0 mL of water and 1.0 mL of ethanol is suspended 0.13 g of 3,5-dihydroxy-6-ethoxycarbonyl-2-pyrazinecarboxamide. At ambient temperature, 0.34 mL of 5 mol/mL sodium hydroxide is added to the suspension, which is then stirred for 16 hours. The reaction mixture is adjusted to pH 2 by adding 1 mol/mL hydrochloric acid. The deposited crystals are collected by filtration and washed with water to obtain 0.07 g of 3,5-dihydroxy-6-carboxy-2-pyrazinecarboxamide.

Workup

  1. filtrationThe deposited crystals are collected by filtration
  2. washwashed with water

Sources & evidence

ORD record
ord-c9d1b68fc669459a826299786846dc5f
Source dataset
uspto-grants-2004_09
Patent number
US06787544B2

Reaction notes

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