反应详情

温度

50 °C

In 4 mL of dimethyl sulfoxide is dissolved 0.4 g of methyl 3-hydroxy-2-pyrazinecarboxlate. Then, 0.27 g of L-aspartic acid and 0.85 mL of triethylamine are successively added to the solution, which is then stirred at 50° C. for 6 hours. The deposited crystals are filtered off, and the filtrate is concentrated under reduced pressure. Then, 2 mL of water and 0.2 mL of methanol are added to the resulting residue. The precipitate formed is collected by filtration to obtain 0.09 g of (2S)-2-{[(3-oxo-3,4-dihydro-2-pyrazinyl)-carbonyl]amino}-butanedioic acid.

1. filtrationThe deposited crystals are filtered off
2. concentrationthe filtrate is concentrated under reduced pressure
3. additionThen, 2 mL of water and 0.2 mL of methanol are added to the resulting residue
4. customThe precipitate formed
5. filtrationis collected by filtration