5-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochloride → 4-{4-[5-(4-Fluorophenyl)pyrimidin-2-yl]piperazine-1-sulfonylmethyl}tetrahydropyran-4-carboxylic acid

HRID 1005856Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1005856
BrC1C=CC([N:8]2[CH2:13][CH2:12][N:11]([S:14]([CH2:17][C:18]3([C:24]([OH:26])=[O:25])[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)(=[O:16])=[O:15])[CH2:10][CH2:9]2)=CC=1.Cl.Cl.[F:29][C:30]1[CH:35]=[CH:34][C:33]([C:36]2[CH:37]=[N:38][C:39](N3CCNCC3)=[N:40][CH:41]=2)=[CH:32][CH:31]=1.COC(C1(S(Cl)(=O)=O)CCOC(C)C1)=O>>[F:29][C:30]1[CH:31]=[CH:32][C:33]([C:36]2[CH:41]=[N:40][C:39]([N:8]3[CH2:13][CH2:12][N:11]([S:14]([CH2:17][C:18]4([C:24]([OH:26])=[O:25])[CH2:19][CH2:20][O:21][CH2:22][CH2:23]4)(=[O:15])=[O:16])[CH2:10][CH2:9]3)=[N:38][CH:37]=2)=[CH:34][CH:35]=1

Komponenten

4

Edukt 3

HCID 226466725-(4-Fluorophenyl)-2-piperazin-1-ylpyrimidine dihydrochlorideHCID 226466794-[4-(4-Bromophenyl)piperazine-1-sulfonylmethyl]tetrahydropyran-4-carboxylic acidHCID 865902444-Chlorosulfonyl-methyltetrahydropyran-4-carboxylic acid methyl ester

Produkt 1

HCID 226467234-{4-[5-(4-Fluorophenyl)pyrimidin-2-yl]piperazine-1-sulfonylmethyl}tetrahydropyran-4-carboxylic acidAusbeute 81 %

Versuchsvorschrift

Prepared according to the method for the preparation of 4-[4-(4-bromophenyl)-piperazine-1-sulfonylmethyl]tetrahydropyran-4-carboxylic acid, from 5-(4-fluoro-phenyl)-2-piperazin-1-ylpyrimidine dihydrochloride (0.27 g), and 4-chlorosulfonyl-methyltetrahydropyran-4-carboxylic acid methyl ester (0.25 g), to yield the title compound as white solid (0.31 g, 81%).

Aufarbeitung

  1. customPrepared

Quellen und Nachweise

ORD-Eintrag
ord-3a93c315df8c4bb7a7bd2ba4f78bb264
Quelldatensatz
uspto-grants-2004_09
Patentnummer
US06787536B2

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